SYNTHESIS OF ENANTIOMERIC PURE INTERMEDIATE FOR THE LACTONE PORTION OF COMPACTIN AND MEVINOLIN

被引：16

作者：

CARDANI, S ^{[1
]}

SCOLASTICO, C ^{[1
]}

VILLA, R ^{[1
]}

机构：

[1] UNIV MILAN,CNR,CTR SOSTANZE ORGAN NAT,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY

来源：

TETRAHEDRON | 1990年 / 46卷 / 20期

关键词：

D O I：

10.1016/S0040-4020(01)87907-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diastereo and enantioselective synthesis of compound 11 a potential useful intermediate for the lactone portion of mevinolin and compactin was developed. Our strategy is based on the high stereoselective Michael addition of alkoxide to chiral norephedrine-derived oxazolidine 4. © 1990.

引用

页码：7283 / 7288

页数：6

共 14 条

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