ROLE OF ANTIGENEMIA ASSAY IN THE EARLY DIAGNOSIS AND PREDICTION OF HUMAN CYTOMEGALOVIRUS ORGAN INVOLVEMENT IN AIDS PATIENTS

被引：26

作者：

FRANCISCI, D

TOSTI, A

PREZIOSI, R

BALDELLI, F

STAGNI, G

PAULUZZI, S

机构：

[1] Institute of Infectious Diseases, University of Perugia, Policlinico Monteluce, Perugia

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1995年 / 14卷 / 06期

关键词：

D O I：

10.1007/BF02113427

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The role of an antigenemia assay in the diagnosis and prediction of human cytomegalovirus (HCMV) disease in AIDS patients was evaluated. The clinical history of 62 patients with advanced HIV infection from whom a total of 248 blood samples were drawn and tested by the HCMV antigenemia assay was examined retrospectively. Between December 1992 and January 1994, 28 episodes of HCMV disease with organ involvement were recorded; the antigenemia assay was positive in 23 of them (82.1 %). In particular, this test was positive in 11 of 12 (91.6 %) first episodes and in 3 of 3 (100 %) recurrent episodes occurring in patients not receiving maintenance therapy. The same test was positive in 9 of 13 (69.2 %) recurrent episodes occurring in patients receiving maintenance therapy. The first occurrence of HCMV disease was always preceded by a positive antigenemia assay 2 and 4 months before diagnosis (in all 7 patients of the 7 for whom a blood sample was available before HCMV disease). A positive antigenemia test result was not always followed by organ involvement, but a high positive cell count (> 100/200,000 polymorphonuclear leukocytes) strongly correlated with the appearance of HCMV disease in the following 1 to 3 months(100 % of cases). The antigenemia assay is a useful and reliable indirect method for the diagnosis and prediction of HCMV endorgan disease in severely and persistently immunocompromised AIDS patients.

引用

页码：498 / 503

页数：6

共 28 条

[21] Revello M.G., Percivalle E., Di Matteo A., Morini F., Gerna G., Nuclear expression of the lower matrix protein of human cytomegalovirus in peripheral blood leukocytes of immunocompromised viraemic patients, Journal of General Virology, 73, pp. 437-442, (1992)
[22] Grefte J.M.M., Van Der Gun B.T.F., Schmolke S., Van Der Giessen M., Van Son W.J., Plachter B., Jahn G., The T.H., Cytomegalovirus antigenemia assay: identification of the viral antigen as the lower matrix protein pp65, Journal of Infectious Diseases, 166, pp. 683-684, (1992)
[23] The T.H., Van Der Ploeg M., Van Den Berg A.P., Vlieger A.M., Van Der Giessen M., Van Son W.J., Direct detection of cytomegalovirus in peripheral blood leukocytes — a review of the antigenemia assay and polymerase chain reaction, Transplantation, 54, pp. 193-198, (1992)
[24] Van Den Berg A.P., Van Der Bij W., Van Son W.J., Anema J., Van Der Giessen M., Schirm J., Tegzess A.M., The T.H., Cytomegalovirus antigenemia as a useful marker of symptomatic cytomegalovirus infection after renal transplantation — a report of 130 consecutive patients, Transplantation, 48, pp. 991-995, (1989)
[25] Boland G.J., De Gast G.C., Hene R.T., Jambroes G., Doncker Wolcke R., The T.H., Mudde G.C., Early detection of active cytomegalovirus (CMV) infection after heart and kidney transplantation by testing for immediate early antigenemia and influence of cellular immunity on the occurrence of CMV infection, Journal of Clinical Microbiology, 28, pp. 2069-2075, (1990)
[26] Zurlo J.J., O'Neill D., Polis M.A., Manischewitz J., Yarcnoan R., Baseler M., Lane H.C., Masur H., Lack of clinical utility of cytomegalovirus blood and urine cultures in patients with HIV infection, Annals of Internal Medicine, 118, pp. 12-17, (1993)
[27] Fay M.T., Freeman W.R., Wiley C.A., Hardy D., Bozzette S., Atypical retinitis in patients with the acquired immunodeficiency syndrome, American Journal of Ophthalmology, 105, pp. 483-490, (1988)
[28] Gallant J.E., Moore R.D., Chaisson R.E., Prophylaxis for opportunistic infections in patients with HIV infection, Annals of Internal Medicine, 120, pp. 932-944, (1994)

← 1 2 3 →