ORGANIZATION AND HETEROGENEITY OF SEQUENCES WITHIN A REPEATING UNIT OF HUMAN Y-CHROMOSOME DEOXYRIBONUCLEIC-ACID

被引：47

作者：

KUNKEL, LM ^{[1
]}

SMITH, KD ^{[1
]}

BOYER, SH ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV HOSP,SCH MED,DEPT MED,DIV MED GENET,BALTIMORE,MD 21205

来源：

BIOCHEMISTRY | 1979年 / 18卷 / 15期

关键词：

D O I：

10.1021/bi00582a022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fragments of 3.4 kilobases (kb) are released from DNA of human males, but not DNA of human females, by cleavage with restriction endonucleases HaeIII, EcoRI, or EcoRII. Most, if not all, reiterated DNA which is specific for the Y chromosome (it-Y DNA) is present within these male-specific 3.4-kb molecules. Although such 3.4-kb molecules are themselves localized to the Y chromosome, this is not true for all sequences within them. At least two distinguishable types of reiterated sequences are found within each 3.4-kb molecule. One type consists of at least two families which are highly reiterated and are not confined to the Y chromosome. The other type is composed of an estimated. © 1979, American Chemical Society. All rights reserved.

引用

页码：3343 / 3353

页数：11

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