EXPRESSION OF MEMBERS OF THE HEAT-SHOCK PROTEIN-70 FAMILY IN THE EXOERYTHROCYTIC STAGES OF PLASMODIUM-BERGHEI AND PLASMODIUM-FALCIPARUM

被引：26

作者：

KUMAR, N

NAGASAWA, H

SACCI, JB

SINA, BJ

AIKAWA, M

ATKINSON, C

UPARANUKRAW, P

KUBIAK, LB

AZAD, AF

HOLLINGDALE, MR

机构：

[1] CASE WESTERN RESERVE UNIV, INST PATHOL, CLEVELAND, OH 44106 USA

[2] BIOMED RES INST, DEPT MALARIA, ROCKVILLE, MD USA

[3] UNIV MARYLAND, SCH MED, DEPT MICROBIOL & IMMUNOL, BALTIMORE, MD 21201 USA

来源：

PARASITOLOGY RESEARCH | 1993年 / 79卷 / 02期

关键词：

D O I：

10.1007/BF00932255

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Exoerythrocytic stages of Plasmodium berghei cultured in HepG2-A16 hepatoma cells and those of P. falciparum in human hepatocytes transplanted under the kidney capsule of CB-17/ICr scid/scid mice were used to evaluate expression of heat-shock-related stress proteins. Although undetectable in the sporozoites, the expression of proteins similar in sequence of a heat-shock protein of 70 kDa and a glucose-regulated protein of 78 kDa was markedly induced in the hepatic stages of malaria parasites. Expression of these proteins in the exoerythrocytic stages of the malaria parasite warrants a systematic evaluation of their potential role in eliciting cellular immune responses directed against infected hepatocytes.

引用

页码：109 / 113

页数：5

共 21 条

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AIKAWA M, 1990, ADV PARASIT, V29, P151, DOI 10.1016/S0065-308X(08)60106-2

[2] A 75 KD MEROZOITE SURFACE PROTEIN OF PLASMODIUM-FALCIPARUM WHICH IS RELATED TO THE 70 KD HEAT-SHOCK PROTEINS [J].