PENETRATION KINETICS OF CIS-DIAMMINEDICHLOROPLATINUM(II) LOADED NANOPARTICLES IN LIPID MONOLAYERS AS A MEMBRANE MODEL OF THE RETICULOENDOTHELIAL SYSTEM

被引:3
作者
EGEA, MA
ALSINA, MA
ESPINA, M
VALLS, O
GARCIA, ML
机构
[1] Department of Pharmacy (Physicochemical Unit), Faculty of Pharmacy, Barcelona University, Barcelona
关键词
D O I
10.1016/0040-6090(92)90258-D
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Using a lipid monolayer as a membrane model of the reticuloendothelial system, the interaction of free cisplatin (CDDP), and CDDP loaded polybutylcyanoacrylate nanoparticles with this lipid film, has been investigated. The kinetics of penetration of this drug into the monolayers at 2.5, 5, 10 and 20 mN m-1 were measured and compared with those of free nanoparticle. The drug associated with the nanoparticles shows a greater increase in surface pressure in the lipid film, than the free drug. This might suggest that association of cisplatin with this carrier could improve its penetration into the reticuloendothelial system model.
引用
收藏
页码:364 / 367
页数:4
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