DEVELOPMENTAL-CHANGES OF FUCOSYLATED GLYCOCONJUGATES IN RABBIT DORSAL-ROOT GANGLIA

被引：20

作者：

KUSUNOKI, S

INOUE, K

IWAMORI, M

NAGAI, Y

MANNEN, T

KANAZAWA, I

机构：

[1] UNIV TOKYO,FAC MED,DEPT BIOCHEM,TOKYO 113,JAPAN

[2] TOKYO METROPOLITAN INST MED SCI,TOKYO 113,JAPAN

来源：

NEUROSCIENCE RESEARCH | 1992年 / 15卷 / 1-2期

关键词：

GANGLIOSIDE; LECTIN; GLYCOPROTEIN; PERIPHERAL NERVE; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0168-0102(92)90019-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Developmental changes of the fucosylated glycoconjugates in the dorsal root ganglia (DRG) of the rabbit were investigated histochemically using anti-fucosyl GM1 antibody and Ulex europaeus agglutinin 1 (UEA-1) lectin. Neither anti-fucosyl GM1 antibody nor UEA-1 lectin bound to the neural tubes or to the neural crest on embryonic day 14 (E14). Anti-fucosyl GM1 antibody binds diffusely to the DRG of E25. Large neurons unreactive with anti-fucosyl GM1 antibody appeared at 1 month and increased within 6 months after birth. Schwann cells immunoreactive with anti-fucosyl GM1 antibody came to be limited to the satellite cells surrounding the positive neurons. No staining with UEA-1 lectin was observed in the DRG of E25. Some small neurons became reactive with UEA-1 lectin within 1 month and remained to be so at 6 months after birth. Schwann cells including satellite cells were unreactive with this lectin. Since fucosyl GM1 was detected in the lipid fraction of DRGs from 1-month-old and 6-month-old rabbits, fucosyl GM1 itself should be the antigen molecule recognized by the anti-fucosyl GM1 antibody. Further study is necessary to elucidate the association between these developmental changes of the fucosylated glycoconjugates in DRG and their possible functional roles.

引用

页码：74 / 80

页数：7

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