1-BETA-METHYLTHIENAMYCIN - SOME STEREOCONTROLLED APPROACHES TOWARDS THE KEY INTERMEDIATE

被引：13

作者：

GURJAR, MK

BHANU, MN

KHARE, VB

BHANDARI, A

DESHMUKH, MN

RAO, AVR

机构：

[1] Indian Institute of Chemical Technology, Hyderabad

来源：

TETRAHEDRON | 1991年 / 47卷 / 34期

关键词：

1-BETA-METHYLTHIENAMYCIN; CARBAPENEM ANTIBIOTICS; STEREOSPECIFIC HYDROGENATION; STEREOSELECTIVE HYDROBORATION; ALLYLIC HYDROXYLATION;

D O I：

10.1016/S0040-4020(01)96165-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two stereocontrolled approaches towards a precursor of 1 beta-methyl-thienamycin, have been accomplished by involving stereospecific hydrogenation of 13 and stereoselective hydroboration oxidation of 9. The latter compounds were obtained from the easily accessible chiral building block 7. The hydroboration-oxidation approach was extended to 18 in which the optically active 1R- (1-hydroxy ethyl) side-chain was incorporated. The highly stereoselective hydroboration-oxidation reaction of 9 is explained by considering Houk's models.

引用

页码：7117 / 7128

页数：12

共 41 条

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