共 21 条
[21]
1990, APR ANN M ROY SOC CH
RING-OPENING OF ISOXAZOLIDINE SYSTEM - HOMOLOGATION OF 3-ARYL INTO 3-STYRYL NITRONES VIA INTERMEDIATE 5-HYDROXY-ISOXAZOLIDINES
被引：7
作者：
CHIACCHIO, U
LIGUORI, A
ROMEO, G
SINDONA, G
UCCELLA, N
机构：
[1] UNIV RENDE,DIPARTIMENTO CHIM,I-87036 RENDE,ITALY
[2] UNIV MESSINA,DIPARTIMENTO FARMACO CHIM,I-98168 MESSINA,ITALY
来源：
关键词：
D O I：
10.1016/S0040-4020(01)88315-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ;
081704 ;
摘要：
High yield conversion of 3-aryl-5-ethoxy-isoxazolidines into 3-styryl nitrones has been achieved by 1,5 h refluxing in aq. H2SO4 or catalytic p-toluensulfonic acid/ethanol media. The rearrangement pathway is interpretable on the basis of the ring-opening process of intermediate 5-hydroxy-isoxazolidines. Formation of a masked 5-OH function has been also developed by basic or acid treatment of 5-acetoxy-isoxazolidines.
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页码：9473 / 9482
页数：10
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