MILD TRAUMATIC BRAIN INJURY ENHANCES MUSCARINIC RECEPTOR-LINKED INOSITOL PHOSPHATE PRODUCTION IN RAT HIPPOCAMPUS

被引：39

作者：

DELAHUNTY, TM

机构：

[1] Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond

来源：

BRAIN RESEARCH | 1992年 / 594卷 / 02期

关键词：

TRAUMATIC BRAIN INJURY; ISCHEMIA; ACETYLCHOLINE; MUSCARINIC; INOSITOL PHOSPHATE; HYPERSENSITIVITY;

D O I：

10.1016/0006-8993(92)91140-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent evidence suggests that muscarinic receptors play a role in the hippocampal hypersensitivity to imposed ischemia following mild traumatic brain injury (TBI). In rat hippocampal tissue, carbachol-stimulated inositol phosphate production was found to be enhanced by mild TBI, at 1 h post injury. This finding suggests that mild TBI may result in enhanced coupling between muscarinic receptors and phosphoinositide hydrolysis, which may contribute to post-traumatic hippocampal vulnerability to secondary ischemia.

引用

页码：307 / 310

页数：4

共 11 条

[1] LITHIUM AMPLIFIES AGONIST-DEPENDENT PHOSPHATIDYLINOSITOL RESPONSES IN BRAIN AND SALIVARY-GLANDS
BERRIDGE, MJ
DOWNES, CP
HANLEY, MR
[J]. BIOCHEMICAL JOURNAL, 1982, 206 (03) : 587 - 595
[2] DEANGELIS M, UNPUB TRAMATIC BRAIN
[3] REGULATION OF GH3-CELL FUNCTION VIA ADENOSINE-A1 RECEPTORS - INHIBITION OF PROLACTIN-RELEASE, CYCLIC-AMP PRODUCTION AND INOSITOL PHOSPHATE GENERATION
DELAHUNTY, TM
CRONIN, MJ
LINDEN, J
[J]. BIOCHEMICAL JOURNAL, 1988, 255 (01) : 69 - 77
[4] GORMAN LK, 1989, J NEUROTRAUM, V6, P203
[5] HAYES RL, 1992, J NEUROTRAUMA S1, V9, P189
[6] Combined Pretrauma Scopolamine and Phencyclidine Attenuate Posttraumatic Increased Sensitivity to Delayed Secondary Ischemia
Jenkins, L. W.
Lyeth, B. G.
Lewelt, W.
Moszynski, K.
Dewitt, D. S.
Balster, R. L.
Miller, L. P.
Clifton, G. L.
Young, H. F.
Hayes, R. L.
[J]. JOURNAL OF NEUROTRAUMA, 1988, 5 (04) : 275 - U40
[7] INCREASED VULNERABILITY OF THE MILDLY TRAUMATIZED RAT-BRAIN TO CEREBRAL-ISCHEMIA - THE USE OF CONTROLLED SECONDARY ISCHEMIA AS A RESEARCH TOOL TO IDENTIFY COMMON OR DIFFERENT MECHANISMS CONTRIBUTING TO MECHANICAL AND ISCHEMIC BRAIN INJURY
JENKINS, LW
MOSZYNSKI, K
LYETH, BG
LEWELT, W
DEWITT, DS
ALLEN, A
DIXON, CE
POVLISHOCK, JT
MAJEWSKI, TJ
CLIFTON, GL
YOUNG, HF
BECKER, DP
HAYES, RL
[J]. BRAIN RESEARCH, 1989, 477 (1-2) : 211 - 224
[8] OUTPUT, TISSUE-LEVELS, AND SYNTHESIS OF ACETYLCHOLINE DURING AND AFTER TRANSIENT FOREBRAIN ISCHEMIA IN THE RAT
KUMAGAE, Y
MATSUI, Y
[J]. JOURNAL OF NEUROCHEMISTRY, 1991, 56 (04) : 1169 - 1173
[9] EFFECTS OF SCOPOLAMINE TREATMENT ON LONG-TERM BEHAVIORAL DEFICITS FOLLOWING CONCUSSIVE BRAIN INJURY TO THE RAT
LYETH, BG
DIXON, CE
JENKINS, LW
HAMM, RJ
ALBERICO, A
YOUNG, HF
STONNINGTON, HH
HAYES, RL
[J]. BRAIN RESEARCH, 1988, 452 (1-2) : 39 - 48
[10] OLENIAK L D, 1988, Society for Neuroscience Abstracts, V14, P1151

← 1 2 →