THE INTERACTION BETWEEN BOVINE HERPESVIRUS TYPE-1 AND ACTIVATED BOVINE LYMPHOCYTE-T

被引：85

作者：

GRIEBEL, PJ

OHMANN, HB

LAWMAN, MJP

BABIUK, LA

机构：

[1] UNIV SASKATCHEWAN, WESTERN COLL VET MED, DEPT VET MICROBIOL, SASKATOON S7N 0W0, SASKATCHEWAN, CANADA

[2] VET INFECT DIS ORG, SASKATOON S7N 0W0, SASKATCHEWAN, CANADA

来源：

JOURNAL OF GENERAL VIROLOGY | 1990年 / 71卷

关键词：

D O I：

10.1099/0022-1317-71-2-369

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The interaction between activated bovine T lymphocytes (BTLs) and bovine herpesvirus type 1 (BHV-1) was investigated. BHV-1 infection of BTLs reduced the amplitude of recombinant bovine interleukin 2-induced proliferative responses. This decreased proliferation was caused by a virus-induced lymhocytolysis which was dependent on viable virus and was not inhibited by recombinant bovine interferon-α(I) 1. Furthermore, lymphocytolysis was not associated with virus replication or with the synthesis of detectable lvels of viral proteins. Electron microscopic examination of virus-infected cells revealed that lymphocytolysis was characterized by early nuclear disintegration resembling apoptosis. These observations suggest that activated T cells, localized at the site of BHV-1 infection, may be susceptible to virus-induced cytolysis.

引用

页码：369 / 377

页数：9