FIRST SYNTHESES OF NOVEL PACLITAXEL(TAXOL) ANALOGS MODIFIED AT THE C4-POSITION

被引：40

作者：

CHEN, SH ^{[1
]}

KADOW, JF ^{[1
]}

FARINA, V ^{[1
]}

FAIRCHILD, CR ^{[1
]}

JOHNSTON, KA ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,PRINCETON,NJ 08543

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 21期

关键词：

D O I：

10.1021/jo00100a011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regiospecific method for the modification of paclitaxel at the C-4 position has been invented, as exemplified by the synthesis of the C-4 cyclopropyl ester of paclitaxel (4) and the C-4 benzoate of paclitaxel (5).

引用

页码：6156 / 6158

页数：3

共 46 条

[11] CHEN SH, 1993, Patent No. 5248796
[12] A HIGHLY EFFICIENT, PRACTICAL APPROACH TO NATURAL TAXOL
DENIS, JN
GREENE, AE
GUENARD, D
GUERITTEVOEGELEIN, F
MANGATAL, L
POTIER, P
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (17) : 5917 - 5919
[13] 1ST HEMISYNTHESIS OF A TAXANE COMPOUND WITH AN OXETANE GROUP IN POSITION 4 (20), 5
ETTOUATI, L
AHOND, A
POUPAT, C
POTIER, P
[J]. TETRAHEDRON, 1991, 47 (47) : 9823 - 9838
[14] FARINA V, 1992, Patent No. 7955008
[15] GEORG GI, 1992, BIOORG MED CHEM LETT, V2, P1751
[16] GEORG GI, 1994, EXPERT OPIN THER PAT, V4, P109
[17] GEORG GI, 1994, 207TH ACS M SAN DIEG
[18] TAXOL AND TAXOTERE - DISCOVERY, CHEMISTRY, AND STRUCTURE-ACTIVITY-RELATIONSHIPS
GUENARD, D
GUERITTEVOEGELEIN, F
POTIER, P
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1993, 26 (04) : 160 - 167
[19] GUERRITTEVOEGEL.F, 1994, 207TH ACS M SAN DIEG
[20] A SIMPLE SYNTHESIS OF 10-DEACETOXYTAXOL DERIVATIVES
HOLTON, RA
SOMOZA, C
CHAI, KB
[J]. TETRAHEDRON LETTERS, 1994, 35 (11) : 1665 - 1668

← 1 2 3 4 5 →