FIRST SYNTHESES OF NOVEL PACLITAXEL(TAXOL) ANALOGS MODIFIED AT THE C4-POSITION

被引:40
作者
CHEN, SH [1 ]
KADOW, JF [1 ]
FARINA, V [1 ]
FAIRCHILD, CR [1 ]
JOHNSTON, KA [1 ]
机构
[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,PRINCETON,NJ 08543
关键词
D O I
10.1021/jo00100a011
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A highly regiospecific method for the modification of paclitaxel at the C-4 position has been invented, as exemplified by the synthesis of the C-4 cyclopropyl ester of paclitaxel (4) and the C-4 benzoate of paclitaxel (5).
引用
收藏
页码:6156 / 6158
页数:3
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