ANTIBODIES TO SYNTHETIC PEPTIDES BASED ON BAND 3 MOTIFS REACT SPECIFICALLY WITH PLASMODIUM-FALCIPARUM (HUMAN MALARIA)-INFECTED ERYTHROCYTES AND BLOCK CYTOADHERENCE

被引：25

作者：

CRANDALL, I

SHERMAN, IW

机构：

[1] University of California Riverside, Riverside

来源：

PARASITOLOGY | 1994年 / 108卷

基金：

美国国家卫生研究院;

关键词：

PLASMODIUM FALCIPARUM; SYNTHETIC PEPTIDES; HUMAN ERYTHROCYTE ANION TRANSPORTER (BAND 3); CYTOADHERENCE;

D O I：

10.1017/S0031182000075934

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Rabbit polyclonal and mouse monoclonal antibodies (Mabs) prepared against synthetic peptides patterned on exofacial loops 3 (amino acids 546-555) and 7 (821-834) of the human anion transport protein band 3 inhibited the cytoadherence of Plasmodium falciparum-infected erythrocytes to C32 amelanotic melanoma cells. Mabs directed against exofacial loop 4 (amino acids 628-642) did not inhibit adherence to a significant degree. The murine Mabs recognized only P. falciparum infected erythrocytes suggesting that the epitopes of loops 3, 4 and 7 are normally cryptic in uninfected erythrocytes.

引用

收藏

页码：389 / 396

页数：8

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