ACCURACY OF HEMODIALYSIS UREA KINETIC MODELING - COMPARISON OF DIFFERENT MODELS

被引:21
作者
BUUR, T [1 ]
LARSSON, R [1 ]
机构
[1] LINKOPING UNIV,DEPT COMP & INFORMAT SCI,S-58183 LINKOPING,SWEDEN
来源
NEPHRON | 1991年 / 59卷 / 03期
关键词
ADEQUACY OF DIALYSIS; COMPUTER; DIALYSATE COLLECTION; HEMODIALYSIS; PROTEIN CATABOLISM; UREA KINETIC MODELING;
D O I
10.1159/000186592
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
To test the accuracy of urea kinetic modeling (UKM), the classic fixed-volume model UKM(f), two variable-volume models (UKM(vb) and UKM(vd)), direct dialysis quantification (DDQ) and a partial dialysate collection method (PDC) were evaluated in 15 stable, high-hematocrit patients. Urea generation rate (G) was also determined from a 1-week collection of total dialysate and urine (OWC). The results, except distribution volumes, were highly correlated. However, Kt/V, the normalized whole-body urea clearance, was about 8% higher with UKM(vb) and UKMvd(vd). Two of three simple equations for Kt/V rendered grossly deviating, but highly correlating, results. The normalized protein catabolic rate was 8% higher with UKM(vd). With OWC as reference, UKM(vb) and UKM(vd) overestimated G by 19 and 15%, respectively. All results of PDC closely followed those of DDQ. This method may be an alternative for exact quantification. Before using a new UKM method it should be compared to an established reference method.
引用
收藏
页码:358 / 363
页数:6
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