COMBINATORIAL CHEMISTRY - APPLICATIONS OF LIGHT-DIRECTED CHEMICAL SYNTHESIS

被引：67

作者：

JACOBS, JW ^{[1
]}

FODOR, SPA ^{[1
]}

机构：

[1] AFFYMETRIX,SANTA CLARA,CA 95051

来源：

TRENDS IN BIOTECHNOLOGY | 1994年 / 12卷 / 01期

关键词：

D O I：

10.1016/0167-7799(94)90007-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Combinatorial methods in biology and chemistry are proving to be powerful methods for generating molecular diversity. One approach, light-directed chemical synthesis, combines semiconductor-based photolithography technologies with solid-phase organic chemistry to synthesize large arrays of molecules with potential biological activity. This novel technology has the potential to provide libraries of both natural and synthetic molecules that might be screened rapidly for biological activity.

引用

页码：19 / 26

页数：8

共 29 条

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