EFFICIENT PREPARATION OF PEPTIDYL PENTAFLUOROETHYL KETONES

被引：29

作者：

ANGELASTRO, MR ^{[1
]}

BURKHART, JP ^{[1
]}

BEY, P ^{[1
]}

PEET, NP ^{[1
]}

机构：

[1] MARION MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(00)92063-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise method for the preparation of alpha-amino pentafluoroethyl ketone salts from amino acids is described. These intermediates are useful for the preparation of peptidyl pentafluoroethyl ketones.

引用

页码：3265 / 3268

页数：4

共 16 条

[11] SYNTHESIS OF PEPTIDYL FLUOROMETHYL KETONES AND PEPTIDYL ALPHA-KETO ESTERS AS INHIBITORS OF PORCINE PANCREATIC ELASTASE, HUMAN NEUTROPHIL ELASTASE, AND RAT AND HUMAN NEUTROPHIL CATHEPSIN-G [J].

PEET, NP ;

BURKHART, JP ;

ANGELASTRO, MR ;

GIROUX, EL ;

MEHDI, S ;

BEY, P ;

KOLB, M ;

NEISES, B ;

SCHIRLIN, D .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) :394-407

[12]

Qui W., 1988, J FLUORINE CHEM, V38, P249

[13] THE SYNTHESIS OF DIHYDROTHIENO[2,3-B]THIOPHENES BY A METAL-HALOGEN EXCHANGE INITIATED INTRAMOLECULAR ACYLATION [J].

SELNICK, HG ;

RADZILOWSKI, EM ;

PONTICELLO, GS .

TETRAHEDRON LETTERS, 1991, 32 (06) :721-724

[14] HIGHLY POTENT AND SPECIFIC INHIBITORS OF HUMAN RENIN [J].

SHAM, HL ;

STEIN, H ;

REMPEL, CA ;

COHEN, J ;

PLATTNER, JJ .

FEBS LETTERS, 1987, 220 (02) :299-301

[15] SYNTHESIS OF PARTIALLY FLUORINATED ANALOGS OF (Z)-5-DECENYL ACETATE - PROBES FOR HYDROPHOBIC INTERACTION IN PHEROMONE RECEPTION [J].

SUN, WC ;

NG, CS ;

PRESTWICH, GD .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (01) :132-137

[16] THE SYNTHESIS OF ARGINYLFLUOROALKANES, THEIR INHIBITION OF TRYPSIN AND BLOOD-COAGULATION SERINE PROTEINASES AND THEIR ANTICOAGULANT ACTIVITY [J].

UEDA, T ;

KAM, CM ;

POWERS, JC .

BIOCHEMICAL JOURNAL, 1990, 265 (02) :539-545

← 1 2 →