INSITU GENERATION OF RUTHENIUM CHIRAL PHOSPHINE COMPLEXES AND THEIR USE IN ASYMMETRIC HYDROGENATION

被引：56

作者：

MANIMARAN, T

WU, TC

KLOBUCAR, WD

KOLICH, CH

STAHLY, GP

FRONCZEK, FR

WATKINS, SE

机构：

[1] ETHYL CORP,CTR TECH,POB 14799,BATON ROUGE,LA 70898

[2] LOUISIANA STATE UNIV,DEPT CHEM,BATON ROUGE,LA 70803

来源：

ORGANOMETALLICS | 1993年 / 12卷 / 04期

关键词：

D O I：

10.1021/om00028a078

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The complexes ((S)-BINAP)Ru(acac)2 (4), (SKEW)Ru(acaC)2 (5), and (DIOP)Ru(acac)2 (6) were generated by hydrogenation of a mixture of the appropriate phosphine and Ru(acac)3 in methanol. Addition of 2-(4-isobutylphenyl)propenoic acid (2) to these solutions, followed by hydrogenation at about 1000 psig, afforded (S)-(+)-ibuprofen in various enantiomeric excesses (about 90% ee using complex 4). A crystal structure was obtained for complex 6.

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页码：1467 / 1470

页数：4

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