COMPACTIN FROM HAJOS (-)-ENEDIONE

被引：10

作者：

DANIEWSKI, AR

USKOKOVIC, MR

机构：

[1] Roche Research Center, Hoffmann La Roche Inc., Nutley

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(00)97906-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from easily accessible (-)-enedione 8, the hexahydronaphthalene part of compactin 1 was synthesized. The most important steps of this synthesis are: reductive alkylation of 8, cyclization of iodide 12 with SmI2 and Zn, and regiospecific dehydrations of 19 and 21 using Marlin reagent. © 1990.

引用

页码：5599 / 5602

页数：4

共 17 条

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