INTERLEUKIN-7 CAN INDUCE THE ACTIVATION OF JAK-1, JAK-3 AND STAT-5 PROTEINS IN MURINE T-CELLS

被引：106

作者：

FOXWELL, BMJ ^{[1
]}

BEADLING, C ^{[1
]}

GUSCHIN, D ^{[1
]}

KERR, I ^{[1
]}

CANTRELL, D ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND, LONDON WC2A 3PX, ENGLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1995年 / 25卷 / 11期

关键词：

INTERLEUKIN-7; INTERLEUKIN-2; SIGNAL TRANSDUCTION; JAK; STAT; TYROSINE KINASE;

D O I：

10.1002/eji.1830251109

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins has recently been linked to the signal transduction mechanism of several cytokines. IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins. The STAT proteins utilized by IL-7 were identical to those induced by IL-2 and could be identified as various STAT 5 isoforms. Moreover, the induction of both Jak 1 and 3, and STAT 5 activity strongly correlated with the growth-promoting effects of IL-7, suggesting that this signal transduction mechanism may play a key role in IL-7-induced proliferation.

引用

页码：3041 / 3046

页数：6

共 51 条

[11] GENE-TRANSFER OF THE INTERLEUKIN (IL)-2 RECEPTOR-BETA CHAIN INTO AN IL-7-DEPENDENT PRE-B-CELL LINE PERMITS IL-2-DRIVEN PROLIFERATION - TYROSINE PHOSPHORYLATION OF SHC IS INDUCED BY IL-2 BUT NOT IL-7 [J].