SYNTHESIS OF MODIFIED NUCLEOSIDES - PALLADIUM-CATALYZED COUPLINGS OF ORGANOSTANNANES OR ORGANOBORANES WITH PYRIMIDINE NUCLEOSIDES

被引：22

作者：

FLYNN, BL ^{[1
]}

MACOLINO, V ^{[1
]}

CRISP, GT ^{[1
]}

机构：

[1] UNIV ADELAIDE,DEPT ORGAN CHEM,POB 498,ADELAIDE,SA 5001,AUSTRALIA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 04期

关键词：

D O I：

10.1080/07328319108046661

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Coupling of suitably protected 5-iodouridine or 5-iodo-2'-deoxyuridine with either arylboronic acids or aryltrimethylstannanes in the presence of a palladium catalyst gave moderate yields of the corresponding 5-aryluridines and 5-aryl-2'-deoxyuridines. 5-Hydroxyuridine was converted into 5-(trifluoromethanesulphonyl)uridine in good yield and the triacetate of this modified nucleoside also underwent palladium-catalysed couplings with a variety of organostannanes to produce the 5-substituted uridine in excellent yield.

引用

页码：763 / 779

页数：17

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