SOLUTION CONFORMATIONS OF THE PITUITARY OPIOID PEPTIDE DYNORPHIN-(1-13)

被引:28
作者
MAROUN, R
MATTICE, WL
机构
关键词
D O I
10.1016/0006-291X(81)90472-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Circular dichroism [CD] spectra were measured for dynorphin-(1-13) in water and in solutions of sodium dodecyl sulfate [SDS] and L-.alpha.-lysophosphatidylcholine (palmitoyl). Spectra in H2O had the features expected for a peptide containing little, if any, order. Small changes are brought about by L-.alpha.-lysophosphatidylcholine (palmitoyl), but the resulting spectrum retained the characteristics expected for a random coil. SDS produced significant changes expected for induction of .alpha. helical content. Quantitative analysis of the CD spectra suggests the conformation changes from .apprx. 5% helix in H2O to 17% helix in SDS. Formulation of the configuration partition function predicts a change in helical content from 1 to 19%. The ordering influence is felt most strongly by those residues immediately following the enkephalin sequence.
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页码:442 / 446
页数:5
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共 16 条
  • [1] CASSIM J Y, 1970, Biopolymers, V9, P1475, DOI 10.1002/bip.1970.360091209
  • [2] A COMPUTERIZED CALIBRATION OF CIRCULAR DICHROMETER
    CASSIM, JY
    YANG, JT
    [J]. BIOCHEMISTRY, 1969, 8 (05) : 1947 - &
  • [3] CIRCULAR-DICHROISM AND PROTON MAGNETIC-RESONANCE STUDIES OF RANDOM CHAIN POLY-L-LYSINE
    EPAND, RM
    WHEELER, GE
    MOSCARELLO, MA
    [J]. BIOPOLYMERS, 1974, 13 (02) : 359 - 369
  • [4] HELIX-COIL STABILITY-CONSTANTS FOR THE NATURALLY-OCCURRING AMINO-ACIDS IN WATER .19. ISOLEUCINE PARAMETERS FROM RANDOM POLY[(HYDROXYPROPYL)GLUTAMINE-CO-L-ISOLEUCINE]
    FREDRICKSON, RA
    CHANG, MC
    POWERS, SP
    SCHERAGA, HA
    [J]. MACROMOLECULES, 1981, 14 (03) : 625 - 632
  • [5] DYNORPHIN-(1-13), AN EXTRAORDINARILY POTENT OPIOID PEPTIDE
    GOLDSTEIN, A
    TACHIBANA, S
    LOWNEY, LI
    HUNKAPILLER, M
    HOOD, L
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (12) : 6666 - 6670
  • [6] COMPUTED CIRCULAR DICHROISM SPECTRA FOR EVALUATION OF PROTEIN CONFORMATION
    GREENFIE.N
    FASMAN, GD
    [J]. BIOCHEMISTRY, 1969, 8 (10) : 4108 - &
  • [7] THE COMPLETE AMINO-ACID-SEQUENCE OF ALPHA-NEO-ENDORPHIN
    KANGAWA, K
    MINAMINO, N
    CHINO, N
    SAKAKIBARA, S
    MATSUO, H
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 99 (03) : 871 - 878
  • [8] LOH HH, 1978, FED PROC, V37, P147
  • [9] OPIATE BINDING TO CEREBROSIDE SULFATE - MODEL SYSTEM FOR OPIATE-RECEPTOR INTERACTION
    LOH, HH
    CHO, TM
    WU, YC
    HARRIS, RA
    WAY, EL
    [J]. LIFE SCIENCES, 1975, 16 (12) : 1811 - 1817
  • [10] LOH HH, 1975, LIFE SCI, V14, P2231