TBE UNIQUE DNA CUTTING SEQUENCE SPECIFICITY OF A 4-(N,N-DIMETHYL-2-AMINOETHYL)AMINO-1,10-PHENANTHROLINE AND ITS 9-AMINOACRIDINE CONJUGATE

被引：4

作者：

CHIU, FCK

BROWNLEE, RTC

MITCHELL, K

PHILLIPS, DR

机构：

[1] LA TROBE UNIV,SCH BIOCHEM,BUNDOORA,VIC 3083,AUSTRALIA

[2] LA TROBE UNIV,SCH CHEM,BUNDOORA,VIC 3083,AUSTRALIA

[3] LA TROBE UNIV,CTR PROT & ENZYME TECHNOL,BUNDOORA,VIC 3083,AUSTRALIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(01)80704-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A 1,10-phenanthroline with a 3-carboxamide and a cationic side chain at C4 shows a highly sequence specific DNA cutting activity at 5'-TTAG sites. Conjugation with an 9-aminoacridine produced an additional cleavage site at 5'-TTAC. A binding model involving a 1:I:1 phenanthroline-copper-DNA complex is proposed based on the copper chelation chemistry of several phenanthroline derivatives.

引用

收藏

页码：2721 / 2726

页数：6

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