INFLUENCE OF HUMAN SERUM ON ANTI-TUMOUR ACTIVITY OF 2 L-ASPARAGINASES

The effect of the addition of human serum on the anti-tumour activity of l-asparaginase, as contained in extracts of E. coli and guinea pig serum, was assessed using the mouse leukaemia system (EARAD/1). It was found that ifhuman serum and E. coli asparaginase were given simultaneously with the inoculation of the tumour cells, then the tumour inhibiting property of the enzyme was increased, whereas this effect was not seen if the asparaginase and serum were given when tumour growth was established. The addition of human to guinea pig serum did not influence its activity whether given when the tumour cells were inoculated, or when the tumour was established. © 1969, The British Empire Cancer Campaign for Research. All rights reserved.