IGA ANTIBODIES FOR DIAGNOSIS OF ACUTE CONGENITAL AND ACQUIRED TOXOPLASMOSIS

被引:116
作者
STEPICKBIEK, P
THULLIEZ, P
ARAUJO, FG
REMINGTON, JS
机构
[1] PALO ALTO MED FDN,RES INST,DEPT IMMUNOL & INFECT DIS,860 BRYANT ST,PALO ALTO,CA 94301
[2] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,STANFORD,CA 94305
[3] INST PUERICULTURE,SEROL NEONATALE & RECH TOXOPLASMOSE,F-75014 PARIS,FRANCE
关键词
D O I
10.1093/infdis/162.1.270
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
An ELISA for IgA toxoplasma antibodies was positive in 12 pregnant women who seroconverted during gestation. Positive IgA titers were also noted in 10 individuals with biopsy-proven toxoplasmic lymphadenitis; the highest titers were noted in the first months following onset of clinical signs. Toxoplasma IgA antibodies were also demonstrable in 8 of 9 infants/fetuses with congenital toxoplasma infection. In some, IgM antibodies could not be demonstrated. Among 20 patients with AIDS and biopsy-proven toxoplasmic encephalitis, only 1 had IgA antibodies. Noneof20 individuals with chronic toxoplasma infectionhad demonstrable IgAantibodies. Demonstration of IgA toxoplasma antibodies should be useful for diagnosis of recently acquired infection and for diagnosis of the infection in the fetus and newborn. © 1990 by The University of Chicago.
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页码:270 / 273
页数:4
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