CHARACTERIZATION OF THE MUSCARINIC RECEPTOR SUBTYPE MEDIATING VASODILATION IN THE RAT PERFUSED MESENTERIC VASCULAR BED PREPARATION

被引:23
作者
HENDRIKS, MGC
PFAFFENDORF, M
VANZWIETEN, PA
机构
[1] Department of Pharmacotherapy, Academic Medical Centre, University of Amsterdam, Amsterdam, 1105 AZ
来源
JOURNAL OF AUTONOMIC PHARMACOLOGY | 1992年 / 12卷 / 06期
关键词
D O I
10.1111/j.1474-8673.1992.tb00389.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1 The nature of the muscarinic receptor subtype mediating endothelium-dependent vascular relaxation was investigated in the perfused mesenteric vascular bed preparation which is a model for resistance vessels. 2 After methoxamine-induced vasoconstriction the vessels were dilated with acetyl-beta-metacholine (MCh). 3 The potency of the M1-selective antagonist pirenzepine, the M2-selective antagonists AF-DX 116 and AQ-RA 741, the M3-selective antagonists 4-DAMP and p-FHHSiD to block the MCh-induced vasodilation was quantified by means of pA2-values. Atropine was used for comparison. 4 The rank order of potency for the various muscarinic receptor antagonists appears to be: atropine>4-DAMP>p-FHHSiD>pirenzepine>AQ-RA 741 >AF-DX 116 which is similar to findings in conduit arteries. 5 The high potency of the M3-selective antagonists 4-DAMP and p-FHHSID and the low potency of the M1- and M2-selective antagonists suggest a major role Of M3-receptors in the cholinergic vasodilatation in the perfused mesenteric vascular bed.
引用
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页码:411 / 420
页数:10
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