An efficient synthesis of 1-aminophosphonic acids and esters bearing heterocyclic moiety

被引：26

作者：

Boduszek, B

机构：

[1] Institute of Organic Chemistry, Biochemistry and Biotechnology, Technical University of Wrocław, 50-370 Wrocław

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1995年 / 104卷 / 1-4期

关键词：

diphenyl alpha-aminofurylmethyl phosphonate alpha-aminothienylmethylphosphonic acid alpha-aminopyrazolylmethylphosphonic acid; imines; benzyl carbamate;

D O I：

10.1080/10426509508042578

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New alpha-aminophosphonic esters and acids derived from furan, thiophene and pyrazole were prepared in high yield, in the reactions of benzylamine, benzhydrylamine or benzyl carbamate with heterocyclic aldehydes and diethyl or diphenyl phosphonates. The protecting groups at amine (benzyl or benzhydryl) were removed by hydrogenolysis or hydrolysis, respectively. The N-benzyloxycarbonyl (Z-group) was removed by treatment with 45% HBr in acetic acid.

引用

页码：63 / 70

页数：8

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