THE SHORT-TERM EFFECTS OF CONJUGATED ESTROGEN ON BONE TURNOVER IN OLDER WOMEN

被引:171
作者
PRESTWOOD, KM
PILBEAM, CC
BURLESON, JA
WOODIEL, FN
DELMAS, PD
DEFTOS, LJ
RAISZ, LG
机构
[1] UNIV CONNECTICUT, CTR HLTH, DIV ENDOCRINOL, FARMINGTON, CT 06030 USA
[2] UNIV CONNECTICUT, CTR HLTH, DEPT BEHAV SCI & COMMUNITY HLTH, FARMINGTON, CT 06030 USA
[3] HOP EDOUARD HERRIOT, F-69437 LYON, FRANCE
[4] UNIV CALIF SAN DIEGO, DEPT MED, SAN DIEGO, CA 92161 USA
[5] VET ADM MED CTR, SAN DIEGO, CA 92161 USA
关键词
D O I
10.1210/jc.79.2.366
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Estrogen replacement therapy (ERT) prevents bone loss and fracture in early postmenopausal women, but its benefit for women over 70 yr of age has not been determined. We have examined the effect of a short course of ERT on biochemical markers of bone turnover in older women. Eleven women (mean age, 77 yr) were given conjugated estrogen (Premarin; 0.625 mg/day) for 6 weeks. Biochemical markers were measured on serum and urine collected at baseline (two samples), after 5 and 6 weeks of ERT, and 5 and 6 weeks post-ERT. Markers of bone formation were osteocalcin, bone alkaline phosphatase, and type I procollagen peptide. Markers of bone resorption were total urinary hydroxyproline, total and free pyridinoline and deoxypyridinoline cross-links, type I collagen cross-linked N-telopeptides, and serum C-terminal cross-linked telopeptide. Data were analyzed by repeated measures multivariate analysis of variance to estimate the overall effect of ERT on the biochemical markers. Markers of bone resorption decreased during ERT and returned to baseline after ERT (P < 0.05). Markers of bone formation declined less during ERT and continued to decline after ERT (P < 0.05). We conclude that ERT reduces bone turnover in older women and that markers of bone turnover may be useful in assessing the response to treatment in this age group.
引用
收藏
页码:366 / 371
页数:6
相关论文
共 29 条
  • [21] QUIGLEY MET, 1987, AM J OBSTET GYNECOL, V156, P1516
  • [22] RIGGS BL, 1992, NEW ENGL J MED, V327, P620
  • [23] INVOLUTIONAL OSTEOPOROSIS
    RIGGS, BL
    MELTON, LJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (26) : 1676 - 1686
  • [24] SCAVENGER FUNCTIONS OF THE LIVER ENDOTHELIAL-CELL
    SMEDSROD, B
    PERTOFT, H
    GUSTAFSON, S
    LAURENT, TC
    [J]. BIOCHEMICAL JOURNAL, 1990, 266 (02) : 313 - 327
  • [25] A RANDOMIZED STUDY ON THE EFFECTS OF ESTROGEN GESTAGEN OR HIGH-DOSE ORAL CALCIUM ON TRABECULAR BONE REMODELING IN POSTMENOPAUSAL OSTEOPOROSIS
    STEINICHE, T
    HASLING, C
    CHARLES, P
    ERIKSEN, EF
    MOSEKILDE, L
    MELSEN, F
    [J]. BONE, 1989, 10 (05) : 313 - 320
  • [26] STEPAN JJ, 1987, BONE, V8, P279
  • [27] EFFECTS OF A SHORT COURSE OF ESTROGEN ON MINERAL METABOLISM IN POSTMENOPAUSAL WOMEN
    STOCK, JL
    CODERRE, JA
    MALLETTE, LE
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 61 (04) : 595 - 600
  • [28] URINARY-EXCRETION OF PYRIDINIUM CROSSLINKS - A NEW MARKER OF BONE-RESORPTION IN METABOLIC BONE-DISEASE
    UEBELHART, D
    GINEYTS, E
    CHAPUY, MC
    DELMAS, PD
    [J]. BONE AND MINERAL, 1990, 8 (01): : 87 - 96
  • [29] EFFECT OF MENOPAUSE AND HORMONE REPLACEMENT THERAPY ON THE URINARY-EXCRETION OF PYRIDINIUM CROSS-LINKS
    UEBELHART, D
    SCHLEMMER, A
    JOHANSEN, JS
    GINEYTS, E
    CHRISTIANSEN, C
    DELMAS, PD
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (02) : 367 - 373