Presbycusis: neural degeneration and aging on the auditory receptor of C57/BL6J mice

被引：4

作者：

Castillo, E. ^{[1
,2
]}

Carricondo, F. ^{[1
]}

Bartolome, M. V. ^{[1
]}

Vicente-Torres, A. ^{[1
]}

Broto, J. Poch ^{[2
]}

Gil-Loyzaga, P. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Med, Dept Oftalmol & Otorrinolaringol, Lab Neurobiol Audic, Madrid, Spain

[2] Univ Complutense Madrid, Fac Med, Dept Oftalmol & Otorrinolaringol, Serv Otorrinolaringol,Hosp Clin San Carlos, Madrid, Spain

来源：

ACTA OTORRINOLARINGOLOGICA ESPANOLA | 2006年 / 57卷 / 09期

关键词：

Presbycusis; Auditory potential; C57/BL6J mice; Presbycusis experimental model;

D O I：

10.1016/S0001-6519(06)78734-9

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Presbycusis is a progressive hearing impairment associated with aging, characterized by hearing loss and a degeneration of cochlear structures. In this paper we analyze the effects of aging on the auditory system of C57/BL6J mice, with electrophysiological and morphological studies. With this aim the auditory potentials of mice aging 1, 3, 6, 9, 12, 15, 18, 21 and 24 months were recorded, and then the morphology of the cochleal were analyzed. Auditory potentials revealed an increase in wave latencies, as well as a decrease in their amplitudes during aging. Morphological results showed a total Corti's organ degeneration, being replaced by a flat epithelial layer, and a total absence of hair cells.

引用

页码：383 / 387

页数：5

共 14 条

[11]

SCHUKNECHT HF, 1993, ANN OTO RHINOL LARYN, V102, P1

[12]

Schuknecht HF, 1993, MALVERN USA, P416

[13] Modulation of presbycusis: Current status and future directions [J].