DESIGN OF POTENT K+ CHANNEL OPENERS BY PHARMACOPHORE MODEL

被引：28

作者：

KOGA, H

OHTA, M

SATO, H

ISHIZAWA, T

NABATA, H

机构：

[1] Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, 412, 1-135, Komakado

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81242-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A pharmacophore model which explains rationally structure-activity relationships of chemically diverse potent K+ channel openers, has been constructed, Potent benzopyran derivatives with thioamide, amide, and (N-cyano)amidine groups at the 4-position have been designed using the model.

引用

收藏

页码：625 / 631

页数：7

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