THE LYME-DISEASE VACCINE CANDIDATE OUTER SURFACE PROTEIN-A (OSPA) IN A FORMULATION COMPATIBLE WITH HUMAN USE PROTECTS MICE AGAINST NATURAL TICK TRANSMISSION OF BORRELIA-BURGDORFERI

被引：30

作者：

GOLDE, WT ^{[1
]}

BURKOT, TR ^{[1
]}

PIESMAN, J ^{[1
]}

DOLAN, MC ^{[1
]}

CAPIAU, C ^{[1
]}

HAUSER, P ^{[1
]}

DEQUESNE, G ^{[1
]}

LOBET, Y ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM BIOL,B-1330 RIXENSART,BELGIUM

来源：

VACCINE | 1995年 / 13卷 / 05期

关键词：

BORRELIA BURGDORFERI; LYME DISEASE; OUTER SURFACE PROTEIN; VACCINE DEVELOPMENT;

D O I：

10.1016/0264-410X(94)00027-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Development of a vaccine for the Lyme disease spirochete, Borrelia burgdorferi, has focused on the bacterial lipoprotein, major outer surface protein A (OspA). With few exceptions, testing of OspA vaccines in animal models has involved challenge with needle inoculation of cultured spirochetes. Recombinant OspA proteins from two OspA divergent strains of B. burgdorferi were tested for their vaccine potential in three different strains of mice challenged with laboratory, reared ticks with a high rate of B. burgdorferi infection. All formulations of the B. burgdorferi sensu stricto derived OspA vaccine protected all strains of mice when challenged by ticks infected with an OspA homologous strain of the spirochete, whereas heterologous OspA from B. afzelii did not protect. Furthermore, ticks feeding on protected mice had reduced OspA levels compared to unvaccinated controls.

引用

页码：435 / 441

页数：7

共 32 条

[1] DELINEATION OF BORRELIA-BURGDORFERI SENSU-STRICTO, BORRELIA-GARINII SP-NOV, AND GROUP VS461 ASSOCIATED WITH LYME BORRELIOSIS [J].