SV40 LARGE T-ANTIGEN WITH C-JUN DOWN-REGULATES MYELIN P-0 GENE-EXPRESSION - A MECHANISM FOR PAPOVAVIRAL T-ANTIGEN-MEDIATED DEMYELINATION

被引：26

作者：

BHARUCHA, VA ^{[1
]}

PEDEN, KWC ^{[1
]}

TENNEKOON, GI ^{[1
]}

机构：

[1] NIH,MOLEC MICROBIOL LAB,BETHESDA,MD 20892

来源：

NEURON | 1994年 / 12卷 / 03期

关键词：

D O I：

10.1016/0896-6273(94)90218-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression of myelin proteins has been shown to be altered in transgenic mice that express papovaviral large tumor (T) antigens. This paper analyzes the effect on P-0 gene expression in secondary Schwann cells transfected with the SV40 T antigen gene and in Schwann cells immortalized by T antigen. In secondary Schwann cells, both T antigen and c-jun are required for significant inhibition of the P-0 promoter; expression of only one of the proteins is insufficient for repression of the P-0 gene. T antigen, c-jun (p39), and c-jun-related protein (p47) form an immunoprecipitable complex in SV40 immortalized Schwann cell lines, and T antigen and c-jun bind independently and as a complex to the P-0 promoter. Our data suggest that the probable molecular mechanism underlying the hypomyelination observed in transgenic animals expressing T antigen may be due to the repression of the P-0 gene by T antigen and c-jun.

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收藏

页码：627 / 637

页数：11

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