THE COMPLETE AMINO-ACID-SEQUENCE FOR BRAIN BETA-SPECTRIN (BETA-FODRIN) - RELATIONSHIP TO GLOBIN SEQUENCES

被引：60

作者：

MA, YP

ZIMMER, WE

RIEDERER, BM

GOODMAN, SR

机构：

[1] UNIV SO ALABAMA, SCH MED, DEPT STRUCT & CELLULAR BIOL, MSB 2042, MOBILE, AL 36688 USA

[2] UNIV LAUSANNE, INST ANAT, CH-1000 LAUSANNE 17, SWITZERLAND

来源：

MOLECULAR BRAIN RESEARCH | 1993年 / 18卷 / 1-2期

关键词：

SPECTRIN; FODRIN; GLOBIN; HEME; ANKYRIN; SYNAPSIN-I;

D O I：

10.1016/0169-328X(93)90176-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The amino acid sequence of mouse brain beta spectrin (beta fodrin), deduced from the nucleotide sequence of complementary DNA clones, reveals that this non-erythroid beta spectrin comprises 2363 residues, with a molecular weight of 274,449 Da. Brain beta spectrin contains three structural domains and we suggest the position of several functional domains including f-actin, synapsin I, ankyrin and spectrin self association sites. Analysis of deduced amino acid sequences indicated striking homology and similar structural characteristics of brain beta spectrin repeats beta11 and beta12 to globins. In vitro analysis has demonstrated that heme is capable of specific attachment to brain spectrin, suggesting possible new functions in electron transfer, oxygen binding, nitric oxide binding or heme scavenging.

引用

页码：87 / 99

页数：13

共 46 条

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