THE EFFECT OF LONG-CHAIN N-ACYLETHANOLAMINES ON SOME MEMBRANE-ASSOCIATED FUNCTIONS OF NEUROBLASTOMA C1300-N18 CELLS

被引：27

作者：

GULAYA, NM ^{[1
]}

MELNIK, AA ^{[1
]}

BALKOV, DI ^{[1
]}

VOLKOV, GL ^{[1
]}

VYSOTSKIY, MV ^{[1
]}

VASKOVSKY, VE ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,INST MARINE BIOL,VLADIVOSTOK,RUSSIA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1152卷 / 02期

关键词：

N-ACYLETHANOLAMINE LIPID; FAST SODIUM ION CHANNEL; N-ACYLETHANOLAMINE MEMBRANE INTERACTION; (NEUROBLASTOMA C1300-N18);

D O I：

10.1016/0005-2736(93)90259-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As reported earlier (Gulaya, N.M., Vaskovsky, V.E., Vysotsky, M.V., Volkov, G.L., Govseeva, N.N. and Artemenko, I.P. (1988) Ukr. Biochim. J. 60, 58-63), N-acylphosphatidylethanolamines (NAPE) and products of their catabolism, N-acylethanolamines (NAE), are present in the lipids of neuroblastoma C1300 N18 undifferentiated cells. The present paper describes the distribution of NAE added to culture medium of differentiated cells and its effect on the fast sodium channels and some other membrane characteristics. It is shown that NAE inhibits the destroying action of veratridine on membranes.

引用

页码：280 / 288

页数：9

共 34 条

[1]

BELENKII BG, 1984, BIOORG KHIM, V10, P224

[2]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

[3] RAPID ISOLATION OF NEURO-BLASTOMA PLASMA-MEMBRANES ON PERCOLL GRADIENTS - CHARACTERIZATION AND LIPID-COMPOSITION [J].