AN ANTI-GP41 HUMAN MONOCLONAL-ANTIBODY THAT ENHANCES HIV-1 INFECTION IN THE ABSENCE OF COMPLEMENT

被引：23

作者：

EATON, AM

UGEN, KE

WEINER, DB

WILDES, T

LEVY, JA

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,CANC RES INST,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT MED,SAN FRANCISCO,CA 94143

[3] UNIV PENN,SCH MED,DEPT MED,PHILADELPHIA,PA 19104

[4] UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1994年 / 10卷 / 01期

关键词：

D O I：

10.1089/aid.1994.10.13

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epstein-Barr virus (EBV) and tested for the production of HIV-1-specific antibodies by ELISA, using purified HIV-1(SF2).2F11, a monoclonal antibody derived from a transformed line, is of the IgG(1) subclass and recognizes an epitope in the conserved region of the envelope transmembrane glycoprotein gp41, which is expressed on the surface of HIV-infected T cells. The antibody does not mediate the lysis of infected T cells in antibody-dependent cellular cytotoxicity (ADCC) assays and does not neutralize the infectivity of HIV-1(SF2) or the homologous isolate HIV-1(TT2).2F11 appears to be the first anti-gp41 human monoclonal antibody that enhances the infectivity of an HIV-1 strain (i.e., SF128A) in the absence of complement.

引用

页码：13 / 18

页数：6

共 29 条

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