THE DOPAMINE-RECEPTOR AGONIST 7-OH-DPAT MODULATES THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE

被引:91
作者
DEFONSECA, FR
RUBIO, P
MARTINCALDERON, JL
CAINE, SB
KOOB, GF
NAVARRO, M
机构
[1] UNIV COMPLUTENSE MADRID, FAC PSICOL, DEPT PSICOBIOL, INST COMPLUTENSE DROGADICC, E-28223 MADRID, SPAIN
[2] Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
关键词
MORPHINE; 7-OH-DPAT; (7-HYDROXY-2-(N; N-DI-N-PROPYLAMINO)TETRALIN); PLACE PREFERENCE; CONDITIONING; DOPAMINE; DOPAMINE D-3 RECEPTOR; (RAT);
D O I
10.1016/0014-2999(94)00708-F
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The present study investigated the effects of systemic administration of the putative dopamine D-3 receptor agonist 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) on the acquisition and expression of morphine-induced place preference in male Wistar rats. Using a a 3-day schedule of conditioning it was found that 7-OH-DPAT in a broad dose range (0.01, 0.25 and 5.0 mg/kg) did not produce significant place preference. However, the administration of either 0.25 or 5.0 mg/kg of 7-OH-DPAT 15 min prior to the exposure to morphine (1 mg/kg) prevented the acquisition of a morphine place preference, whereas the 0.01 mg/kg dose of the dopamine receptor agonist was uneffective. In addition, when 7-OH-DPAT was acutely administered 15 min prior to the testing session of an already established morphine place preference, the 0.01 mg/kg dose prevented the expression of this conditioned response. This effect was not observed with either 0.25 and 5.0 mg/kg doses of this dopamine D-3 receptor agonist. It was suggested that the different dose related effects of 7-OH-DPAT on the acquisition and expression of morphine place preference might be related to the intrinsic ability of this agonist for interacting with pre- and postsynaptic dopamine D-3 receptors located in limbic projecting areas of the mesencephalic dopamine system, although involvement of dopamine D-2 receptors cannot be excluded. The pattern of effects seen with 7-OH-DPAT suggests that it may be useful for treating opiate dependence and craving.
引用
收藏
页码:47 / 55
页数:9
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