SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN AND CAFFEINE IN TABLET PREPARATIONS BY PARTIAL LEAST-SQUARES MULTIVARIATE SPECTROPHOTOMETRIC CALIBRATION

被引:43
作者
BOZDOGAN, A
ACAR, AM
KUNT, GK
机构
[1] Yildiz University, Department of Chemistry, Şişli, Istanbul
关键词
D O I
10.1016/0039-9140(92)80281-H
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The use of partial least-squares spectrophotometric calibration for the simultaneous determination of analgesic tablets in a multicomponent formulation is presented. This method is applied to the determination of acetaminophen and caffeine in tablet preparations. The results show that these components in a molar ratio of about 21:1 in tablets have been determined simultaneously with high precision.
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页码:977 / 979
页数:3
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