THE CCK-B/GASTRIN RECEPTOR - IDENTIFICATION OF AMINO-ACIDS THAT DETERMINE NONPEPTIDE ANTAGONIST AFFINITY

被引：14

作者：

KOPIN, AS ^{[1
]}

BEINBORN, M ^{[1
]}

LEE, YM ^{[1
]}

MCBRIDE, EW ^{[1
]}

QUINN, SM ^{[1
]}

机构：

[1] TUFTS UNIV,NEW ENGLAND MED CTR,SCH MED,GRASP DIGEST DIS CTR,BOSTON,MA 02111

来源：

CHOLECYSTOKININ | 1994年 / 713卷

关键词：

D O I：

10.1111/j.1749-6632.1994.tb44053.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：67 / 78

页数：12

共 20 条

[1] A SINGLE AMINO-ACID OF THE CHOLECYSTOKININ-B GASTRIN RECEPTOR DETERMINES SPECIFICITY FOR NONPEPTIDE ANTAGONISTS [J].

BEINBORN, M ;

LEE, YM ;

MCBRIDE, EW ;

QUINN, SM ;

KOPIN, AS .

NATURE, 1993, 362 (6418) :348-350

[2] BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF AN EXTREMELY POTENT AND SELECTIVE NONPEPTIDE CHOLECYSTOKININ ANTAGONIST [J].

CHANG, RSL ;

LOTTI, VJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) :4923-4926

[3] RELEASE OF INTRACELLULAR CA-2+ AND ELEVATION OF INOSITOL TRISPHOSPHATE BY SECRETAGOGUES IN PARIETAL AND CHIEF CELLS ISOLATED FROM RABBIT GASTRIC-MUCOSA [J].

CHEW, CS ;

BROWN, MR .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 888 (01) :116-125

[4] MODEL SYSTEMS FOR THE STUDY OF 7-TRANSMEMBRANE-SEGMENT RECEPTORS [J].

DOHLMAN, HG ;

THORNER, J ;

CARON, MG ;

LEFKOWITZ, RJ .

ANNUAL REVIEW OF BIOCHEMISTRY, 1991, 60 :653-688

[5] RATIONALLY DESIGNED DIPEPTOID ANALOGS OF CCK - ALPHA-METHYLTRYPTOPHAN DERIVATIVES AS HIGHLY SELECTIVE AND ORALLY ACTIVE GASTRIN AND CCK-B ANTAGONISTS WITH POTENT ANXIOLYTIC PROPERTIES [J].

HORWELL, DC ;

HUGHES, J ;

HUNTER, JC ;

PRITCHARD, MC ;

RICHARDSON, RS ;

ROBERTS, E ;

WOODRUFF, GN .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) :404-414

[6] DEVELOPMENT OF A CLASS OF SELECTIVE CHOLECYSTOKININ TYPE-B RECEPTOR ANTAGONISTS HAVING POTENT ANXIOLYTIC ACTIVITY [J].

HUGHES, J ;

BODEN, P ;

COSTALL, B ;

DOMENEY, A ;

KELLY, E ;

HORWELL, DC ;

HUNTER, JC ;

PINNOCK, RD ;

WOODRUFF, GN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6728-6732

[7]

JENSEN RT, 1990, GASTROINTEST ENDOSC, P95

[8] CYSTEINE RESIDUE-110 AND RESIDUE-187 ARE ESSENTIAL FOR THE FORMATION OF CORRECT STRUCTURE IN BOVINE RHODOPSIN [J].

KARNIK, SS ;

SAKMAR, TP ;

CHEN, HB ;

KHORANA, HG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (22) :8459-8463

[9] EXPRESSION CLONING AND CHARACTERIZATION OF THE CANINE PARIETAL-CELL GASTRIN RECEPTOR [J].

KOPIN, AS ;

LEE, YM ;

MCBRIDE, EW ;

MILLER, LJ ;

LU, M ;

LIN, HY ;

KOLAKOWSKI, LF ;

BEINBORN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3605-3609

[10]

LEE YM, 1993, J BIOL CHEM, V268, P8164

← 1 2 →