VITAMIN-K STATUS OF FREE-LIVING SUBJECTS CONSUMING OLESTRA

被引：37

作者：

JONES, DY ^{[1
]}

KOONSVITSKY, BP ^{[1
]}

EBERT, ML ^{[1
]}

JONES, MB ^{[1
]}

LIN, PYT ^{[1
]}

WILL, BH ^{[1
]}

SUTTIE, JW ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1991年 / 53卷 / 04期

关键词：

OLESTRA; SUCROSE POLYESTER; VITAMIN-K; PHYLLOQUINONE; BIOAVAILABILITY;

D O I：

10.1093/ajcn/53.4.943

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The potential for 20 g olestra/d to affect vitamin K status was assessed in a 6-wk study involving 202 free-living subjects. Functional prothrombin [Simplastin(R) (S)-Ecarin(R) (E) assay] concentrations and classical clotting times were unaffected by olestra. Initial S:E values were 0.80 and 0.79 for the olestra and placebo groups, respectively, compared with a value of 0.92 for normal reference plasma. At week 6 the value was 0.81 for both groups. Mean phylloquinone serum concentrations, expressed as differences from baseline, were not significantly different between groups. Weekly food diaries indicated that the average phylloquinone intake of the subjects was low, approximately 60-mu-g/d. Sensitive measures of vitamin K status were unaffected in a population where any significant decerese in phylloquinone bioavailability should have been reflected in those measures, indicating that 20 g olestra/d in the diet did not affect vitamin K status.

引用

页码：943 / 946

页数：4

共 21 条

[1]

ALLISON PM, 1987, J LAB CLIN MED, V110, P180

[2]

BLANCHARD RA, 1983, J LAB CLIN MED, V101, P242

[3]

Elliott MC, 1940, P SOC EXP BIOL MED, V43, P240

[4] SUCROSE POLYESTER AND COVERT CALORIC DILUTION [J].