SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING 4'-C-(HYDROXYMETHYL)THYMIDINE - NOVEL PROMISING ANTISENSE MOLECULES

被引：24

作者：

FENSHOLDT, J ^{[1
]}

THRANE, H ^{[1
]}

WENGEL, J ^{[1
]}

机构：

[1] ODENSE UNIV,DEPT CHEM,DK-5230 ODENSE M,DENMARK

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 14期

关键词：

D O I：

10.1016/0040-4039(95)00301-R

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4'-C-(Hydroxymethyl)thymidine derivative 1 was transformed into phosphoramidite 7 which was used for incorporation of 4'-C-hydroxymethyl functionalized thymidine monomers once and twice into 17-mer oligodeoxynucleotides (ODNs). The novel modified ODNs exhibited excellent affinity towards complementary DNA and increased resistance towards 3'-exonucleolytic degradation compared to unmodified ODNs.

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收藏

页码：2535 / 2538

页数：4

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