INDUCTION OF GLUTATHIONE-S-TRANSFERASE P-FORM IN PRIMARY CULTURED RAT-LIVER PARENCHYMAL-CELLS BY COPLANAR POLYCHLORINATED BIPHENYL CONGENERS

被引：25

作者：

AOKI, Y ^{[1
]}

SATOH, K ^{[1
]}

SATO, K ^{[1
]}

SUZUKI, KT ^{[1
]}

机构：

[1] HIROSAKI UNIV, SCH MED, DEPT BIOCHEM, HIROSAKI, AOMORI 036, JAPAN

来源：

BIOCHEMICAL JOURNAL | 1992年 / 281卷

关键词：

D O I：

10.1042/bj2810539

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alterations in protein synthesis in primary cultured rat liver parenchymal cells were examined after their exposure to the potent carcinogens, polychlorinated biphenyl (PCB) congeners. Co-planar PCB congeners (3,4,5,3',4'-PCB and 3,4,5,3',4',5'-PCB) (10 nM) induced a protein, the M(r) of which was 25 000 (25 k protein) under denaturing conditions. However, non-co-planar PCB congeners and several xenobiotics, which induce microsomal proteins, did not induce the 25 k protein. By using immunoblotting, the 25 k protein was identified as glutathione S-transferase P-form (GST-P, 7-7, EC 2.5.1.18).

引用

页码：539 / 543

页数：5

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