THE DISTRIBUTION OF ANGIOTENSIN-II AT1 RECEPTOR SUBTYPE MESSENGER-RNA IN THE RAT-BRAIN

被引：69

作者：

BUNNEMANN, B

IWAI, N

METZGER, R

FUXE, K

INAGAMI, T

GANTEN, D

机构：

[1] KAROLINSKA INST,DEPT HISTOL & NEUROBIOL,BOX 60400,S-10401 STOCKHOLM 60,SWEDEN

[2] VANDERBILT UNIV,MED CTR,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

[3] UNIV HEIDELBERG,DEPT PHARMACOL,W-6900 HEIDELBERG,GERMANY

[4] MAX DELBRUCK CTR MOLEC MED,BERLIN,GERMANY

来源：

NEUROSCIENCE LETTERS | 1992年 / 142卷 / 02期

关键词：

ANGIOTENSIN-II AT1 RECEPTOR SUBTYPE; MESSENGER RNA; BRAIN; INSITU HYBRIDIZATION; RAT;

D O I：

10.1016/0304-3940(92)90362-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The present study demonstrates the existence and regional distribution of angiotensin II AT1 receptor subtype mRNA expression in the rat brain by the use of in situ hybridization and RNase protection assay. Substantial expression levels in the brain have only been detected in certain distinct areas, such as the subfornical organ, the parvocellular part of the paraventricular hypothalamic nucleus, and the median preoptic nucleus. The results give further evidence for the involvement of the angiotensin II AT1 receptor subtype in the classical functions of central angiotensin II, like blood pressure control, body fluid homeostasis and in corticotropin-releasing factor (CRF) secretion.

引用

页码：155 / 158

页数：4

共 19 条

[1]

BALLA T, 1991, MOL PHARMACOL, V40, P401

[2]

BUNNEMANN B, 1991, ADV NEUROSC, V1, P131

[3]

ANGIOTENSIN-II RECEPTORS IN PARAVENTRICULAR NUCLEUS, SUBFORNICAL ORGAN, AND PITUITARY-GLAND OF HYPOPHYSECTOMIZED, ADRENALECTOMIZED, AND VASOPRESSIN-DEFICIENT RATS [J].