IDENTIFICATION OF AN INTERLEUKIN 2-LIKE SUBSTANCE AS A FACTOR CYTOTOXIC TO OLIGODENDROCYTES AND ASSOCIATED WITH CENTRAL-NERVOUS-SYSTEM REGENERATION

被引：67

作者：

EITAN, S ^{[1
]}

ZISLING, R ^{[1
]}

COHEN, A ^{[1
]}

BELKIN, M ^{[1
]}

HIRSCHBERG, DL ^{[1
]}

LOTAN, M ^{[1
]}

SCHWARTZ, M ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT NEUROBIOL,IL-76100 REHOVOT,ISRAEL

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 12期

关键词：

CYTOTOXICITY; LYMPHOKINES; NERVE INJURY; NERVE REGENERATION;

D O I：

10.1073/pnas.89.12.5442

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Axons of the central nervous system in adult mammals do not regenerate spontaneously after injury, partly because of the presence of oligodendrocytes that inhibit axonal growth. This is not the case in lower vertebrates (e.g., in fish), where regeneration of the optic nerve does occur spontaneously and has been correlated with the presence of factors cytotoxic to oligodendrocytes. The present study provides evidence that the substance originating from the fish optic nerves, which is cytotoxic to oligodendrocytes, is an interleukin 2-like substance.

引用

页码：5442 / 5446

页数：5

共 32 条

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