INHIBITION OF THIOGLUCOSIDASE-CATALYZED GLUCOSINOLATE HYDROLYSIS BY CASTANOSPERMINE AND RELATED ALKALOIDS

被引：34

作者：

SCOFIELD, AM ^{[1
]}

ROSSITER, JT ^{[1
]}

WITHAM, P ^{[1
]}

KITE, GC ^{[1
]}

NASH, RJ ^{[1
]}

FELLOWS, LE ^{[1
]}

机构：

[1] ROYAL BOT GARDENS,JODRELL LAB,RICHMOND TW9 3DS,SURREY,ENGLAND

来源：

PHYTOCHEMISTRY | 1990年 / 29卷 / 01期

关键词：

alexine; Brassica nigra; cabbage aphid; castanospermine; Cruciferae; glucosinolate hydrolysis; homonojirimycin; mustard; myrosinase; progoitrin; sinigrin; thioglucosidase;

D O I：

10.1016/0031-9422(90)89021-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of some naturally occurring polyhydroxyalkaloids to inhibit the hydrolysis of the glucosinolates, sinigrin (allylglucosinolate) and progoitrin [(2R)-2-hydroxybut-3-enylglucosinolate], by thioglucosidases from mustard and the cabbage aphid, Brevicoryne brassicae, was assessed. Several compounds, in particular castanospermine, DMDP and alexine were effective. The inhibitory activity varied according to substrate, buffer composition and pH, and enzyme source. © 1990.

引用

页码：107 / 109

页数：3

共 19 条

[1] INHIBITION OF HUMAN ALPHA-D-GLUCOSIDASES AND BETA-D-GLUCOSIDASES AND ALPHA-D-MANNOSIDASES AND BETA-D-MANNOSIDASES BY 2,5-DIHYDROXYMETHYL-3,4-DIHYDROXYPYRROLIDINE
DIBELLO, IC
DORLING, P
EVANS, S
FELLOWS, L
WINCHESTER, B
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1985, 13 (06) : 1127 - 1128
[2] ETTLINGER MG, 1950, J AM CHEM SOC, P4792
[3] THE BIOLOGICAL-ACTIVITY OF POLYHYDROXYALKALOIDS FROM PLANTS
FELLOWS, LE
[J]. PESTICIDE SCIENCE, 1986, 17 (05): : 602 - 606
[4] FELLOWS LE, 1989, IN PRESS RECENT ADV, V23
[5] FELLOWS LE, 1988, NATURAL PRODUCT ISOL, P540
[6] DETERMINATION OF PROTEIN - MODIFICATION OF LOWRY METHOD THAT GIVES A LINEAR PHOTOMETRIC RESPONSE
HARTREE, EF
[J]. ANALYTICAL BIOCHEMISTRY, 1972, 48 (02) : 422 - &
[7] Heaney R.K., 1986, TECHNICAL B ANAL GLU
[8] ALPHA-HOMONOJIRIMYCIN [2,6-DIDEOXY-2,6-IMINO-D-GLYCERO-L-GULO-HEPTITOL] FROM OMPHALEA-DIANDRA L - ISOLATION AND GLUCOSIDASE INHIBITION
KITE, GC
FELLOWS, LE
FLEET, GWJ
LIU, PS
SCOFIELD, AM
SMITH, NG
[J]. TETRAHEDRON LETTERS, 1988, 29 (49) : 6483 - 6486
[9] COMPARISON OF KINETIC AND MOLECULAR-PROPERTIES OF 2 FORMS OF AMYGDALIN HYDROLASE FROM BLACK-CHERRY (PRUNUS-SEROTINA EHRH) SEEDS
KUROKI, GW
POULTON, JE
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1986, 247 (02) : 433 - 439
[10] ISOLATION AND CHARACTERIZATION OF MULTIPLE FORMS OF PRUNASIN HYDROLASE FROM BLACK-CHERRY (PRUNUS-SEROTINA EHRH) SEEDS
KUROKI, GW
POULTON, JE
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1987, 255 (01) : 19 - 26

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