INHIBITORY ACTIVITIES OF HERPES-SIMPLEX VIRUSES TYPE-1 AND TYPE-2 AND HUMAN CYTOMEGALOVIRUS BY STEREOISOMERS OF 2'-DEOXY-3'-OXA-5(E)-(2-BROMOVINYL)URIDINES AND THEIR 4'-THIO ANALOGS

被引：12

作者：

BEDNARSKI, K

DIXIT, DM

WANG, W

EVANS, CA

JIN, HL

YUEN, L

MANSOUR, TS

机构：

[1] BIOCHEM THERAPEUT INC,LAVAL H7V 4A7,PQ,CANADA

[2] GLAXO RES & DEV LTD,DEPT VIROL,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(01)80693-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two series of optically pure 2,4-disubstituted 1,3-dioxolanes and -1,3-oxathiolane nucleosides containing (E)-5-(2-bromovinyl)uracil were synthesized and assayed for activity against HSV-1, HSV-2 and HCMV replication in vitro. The beta-L (2S,4S) dioxolane nucleoside 10 displayed significant activity against HSV-1, whereas the beta-D (2R,4R) oxathiolane 14 demonstrated potent activity against HSV-2. The alpha-L (2S,4R) dioxolane 11 and oxathiolane 17 were moderately active against HSV-1 and HSV-2, respectively.

引用

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页码：2667 / 2672

页数：6

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