SCHWANN-CELLS IN NEUROBLASTOMA

被引:34
作者
AMBROS, IM [1 ]
AMBROS, PF [1 ]
机构
[1] UNIV VIENNA, INST CLIN PATHOL, A-1090 VIENNA, AUSTRIA
关键词
NEUROBLASTOMA; MATURATION; REGRESSION; SCHWANN CELLS; SCHWANN CELL-AXON INTERACTIONS; GROWTH FACTORS; IN SITU HYBRIDIZATION; 1P DELETION; PLOIDY;
D O I
10.1016/0959-8049(95)00051-J
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Why should we consider Schwann cells when we are interested in the biology of neuroblastomas (NBs)? Although we are familiar with the term ''stroma-rich'' NB, we basically think of a favourable prognostic subgroup, histologically distinguished by the development of a prominent Schwann cell-stroma. According to current opinion on the maturation processes in NBs, the NB-associated Schwann cell is believed to represent a differentiation product of the NB cell, and we therefore do not envisage the Schwann cell as having any important role in NBs. However, our interest was raised after having realised that Schwann cells in NBs are normal cells, very likely attracted to the neoplastic neuroblasts. But what role does this cell play in these tumours? Can we still reduce the appearance of Schwann cells in NBs to an epi-phenomenon or is this cell population responsible for the differentiation of certain NBs? If so, will it be possible to use their strategies to induce differentiation of neuroblasts and so render them non-aggressive, mature ganglionic cells? To shed light on the possible interactions between normal Schwann cells and NB cells, the maturation capacity of NBs and the genetic constitution of the two main cell populations in these tumours are briefly reviewed. Some data leading to the current view on the origin of the Schwann cells in NBs, and several physiological aspects of the Schwann cells, including normal neurone-Schwann cell interactions, are detailed.
引用
收藏
页码:429 / 434
页数:6
相关论文
共 83 条
[41]   ANTIPROLIFERATIVE FUNCTION OF GLIA MATURATION FACTOR-BETA [J].
LIM, R ;
ZHONG, WX ;
ZAHEER, A .
CELL REGULATION, 1990, 1 (10) :741-746
[42]   GLIA MATURATION FACTOR-BETA REGULATES THE GROWTH OF N18 NEUROBLASTOMA-CELLS [J].
LIM, R ;
LIU, YX ;
ZAHEER, A .
DEVELOPMENTAL BIOLOGY, 1990, 137 (02) :444-450
[43]   CLINICAL RELEVANCE OF TUMOR-CELL PLOIDY AND N-MYC GENE AMPLIFICATION IN CHILDHOOD NEUROBLASTOMA - A PEDIATRIC ONCOLOGY GROUP-STUDY [J].
LOOK, AT ;
HAYES, FA ;
SHUSTER, JJ ;
DOUGLAS, EC ;
CASTLEBERRY, RP ;
BOWMAN, LC ;
SMITH, EI ;
BRODEUR, GM .
JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (04) :581-591
[44]   GLIAL GROWTH-FACTORS ARE ALTERNATIVELY SPLICED ERBB2 LIGANDS EXPRESSED IN THE NERVOUS-SYSTEM [J].
MARCHIONNI, MA ;
GOODEARL, ADJ ;
CHEN, MS ;
BERMINGHAMMCDONOGH, O ;
KIRK, C ;
HENDRICKS, M ;
DANEHY, F ;
MISUMI, D ;
SUDHALTER, J ;
KOBAYASHI, K ;
WROBLEWSKI, D ;
LYNCH, C ;
BALDASSARE, M ;
HILES, I ;
DAVIS, JB ;
HSUAN, JJ ;
TOTTY, NF ;
OTSU, M ;
MCBURNEY, RN ;
WATERFIELD, MD ;
STROOBANT, P ;
GWYNNE, D .
NATURE, 1993, 362 (6418) :312-318
[45]   EXCELLENT OUTCOME OF STAGE-II NEURO-BLASTOMA IS INDEPENDENT OF RESIDUAL DISEASE AND RADIATION-THERAPY [J].
MATTHAY, KK ;
SATHER, HN ;
SEEGER, RC ;
HAASE, GM ;
HAMMOND, GD .
JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (02) :236-244
[46]   NEURONAL STIMULATION OF [H-3]THYMIDINE INCORPORATION BY PRIMARY CULTURES OF HIGHLY PURIFIED NON-NEURONAL CELLS [J].
MCCARTHY, KD ;
PARTLOW, LM .
BRAIN RESEARCH, 1976, 114 (03) :415-426
[47]   SYNTHESIS AND EFFECTS OF BASEMENT-MEMBRANE COMPONENTS IN CULTURED RAT SCHWANN-CELLS [J].
MCGARVEY, ML ;
BARONVANEVERCOOREN, A ;
KLEINMAN, HK ;
DUBOISDALCQ, M .
DEVELOPMENTAL BIOLOGY, 1984, 105 (01) :18-28
[48]   MYELIN-SPECIFIC PROTEINS AND GLYCOLIPIDS IN RAT SCHWANN-CELLS AND OLIGODENDROCYTES IN CULTURE [J].
MIRSKY, R ;
WINTER, J ;
ABNEY, ER ;
PRUSS, RM ;
GAVRILOVIC, J ;
RAFF, MC .
JOURNAL OF CELL BIOLOGY, 1980, 84 (03) :483-494
[49]   N-MYC ONCOGENE AMPLIFICATION AND PROGNOSTIC FACTORS OF NEUROBLASTOMA IN CHILDREN [J].
NAKAGAWARA, A ;
IKEDA, K ;
TSUDA, T ;
HIGASHI, K .
JOURNAL OF PEDIATRIC SURGERY, 1987, 22 (10) :895-898
[50]  
NAKAGAWARA A, 1992, CANCER RES, V52, P1364