IS DEHYDROEPIANDROSTERONE AN ANTIOBESITY AGENT

被引：64

作者：

BERDANIER, CD ^{[1
]}

PARENTE, JA ^{[1
]}

MCINTOSH, MK ^{[1
]}

机构：

[1] UNIV N CAROLINA,DEPT FOODS & NUTR,GREENSBORO,NC 27412

来源：

FASEB JOURNAL | 1993年 / 7卷 / 05期

关键词：

DEHYDROPIANDROSTERONE; OBESITY; LIPOGENESIS; PEROXISOMES; MITOCHONDRIAL RESPIRATION; ENERGY BALANCE;

D O I：

10.1096/fasebj.7.5.8462783

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The steroid hormone intermediate, DHEA, has been proposed as a therapeutic agent for the treatment of obesity. Its effects on lipogenesis, substrate cycling, peroxisome proliferation, mitochondrial respiration, protein synthesis, and thyroid hormone function have been reported. The results of these studies suggest that the antiobesity function of DHEA is not simply one of inhibiting fat synthesis and deposition but is one of affecting a number of pathways that contribute to the maintenance of the isoenergetic state rather than the promotion of positive energy balance.

引用

页码：414 / 419

页数：6

共 65 条

[1] CHANGES IN LIVER STRUCTURE AND FUNCTION AFTER SHORT-TERM AND LONG-TERM TREATMENT OF RATS WITH DEHYDROEPIANDROSTERONE [J].

BELLEI, M ;

BATTELLI, D ;

FORNIERI, C ;

MORI, G ;

MUSCATELLO, U ;

LARDY, H ;

BOBYLEVA, V .

JOURNAL OF NUTRITION, 1992, 122 (04) :967-976

[2] ROLE OF GLUCOCORTICOIDS IN THE REGULATION OF LIPOGENESIS [J].

BERDANIER, CD .

FASEB JOURNAL, 1989, 3 (10) :2179-2183

[3]

BERDANIER CD, 1989, P SOC EXP BIOL MED, V192, P242, DOI 10.3181/00379727-192-42992

[4]

BERDANIER CD, 1988, FRONTIERS DIABETES R, P356

[5] REGULATION OF CARNITINE ACYLTRANSFERASE SYNTHESIS IN LEAN AND OBESE ZUCKER RATS BY DEHYDROEPIANDROSTERONE AND CLOFIBRATE [J].

BRADY, LJ ;

RAMSAY, RR ;

BRADY, PS .

JOURNAL OF NUTRITION, 1991, 121 (04) :525-531

[6] HYPOTHALAMIC AND GENETIC OBESITY IN EXPERIMENTAL-ANIMALS - AUTONOMIC AND ENDOCRINE HYPOTHESIS [J].

BRAY, GA ;

YORK, DA .

PHYSIOLOGICAL REVIEWS, 1979, 59 (03) :719-809

[7] OBESITY, A DISORDER OF NUTRIENT PARTITIONING - THE MONA-LISA HYPOTHESIS [J].

BRAY, GA .

JOURNAL OF NUTRITION, 1991, 121 (08) :1146-1162

[8] THE EFFECT OF DEHYDROEPIANDROSTERONE ON LIVER METABOLITES [J].

CASAZZA, JP ;

SCHAFFER, WT ;

VEECH, RL .

JOURNAL OF NUTRITION, 1986, 116 (02) :304-310

[9] EFFECTS OF DEXAMETHASONE ON KINETICS AND DISTRIBUTION OF TRIIODOTHYRONINE IN THE RAT [J].

CAVALIERI, RR ;

CASTLE, JN ;

MCMAHON, FA .

ENDOCRINOLOGY, 1984, 114 (01) :215-221

[10] EFFECTS OF SHORT-TERM DEHYDROEPIANDROSTERONE TREATMENT ON SERUM AND PANCREATIC INSULIN IN ZUCKER RATS [J].

CLEARY, MP ;

ZABEL, T ;

SARTIN, JL .

JOURNAL OF NUTRITION, 1988, 118 (03) :382-387

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