IDENTIFICATION OF A NOVEL SUGAR, 4-AMINO-4,6-DIDEOXY-2-O-METHYLMANNOSE IN THE LIPOPOLYSACCHARIDE OF VIBRIO-CHOLERAE O1 SEROTYPE OGAWA

被引:64
作者
ITO, T [1 ]
HIGUCHI, T [1 ]
HIROBE, M [1 ]
HIRAMATSU, K [1 ]
YOKOTA, T [1 ]
机构
[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN
关键词
D O I
10.1016/0008-6215(94)84231-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A novel sugar in the lipopolysaccharide of Vibrio cholerae O1 serotype Ogawa has been identified. The sugar was liberated from the lipopolysaccharide when hydrolyzed in 10 M HCl at 90-degrees-C for 15 min. The sugar was purified and identified as 4-amino-4,6-dideoxy-2-O-methylmannose (2-O-methylperosamine). Since it was found only in the lipopolysaccharide of Vibrio cholerae O1 serotype Ogawa, it seems that the sugar is one of the specific constituents determining Ogawa serotype specificity.
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页码:113 / 128
页数:16
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