CLONING AND CHARACTERIZATION OF WNT-4 AND WNT-LL CDNAS FROM CHICK-EMBRYO

被引：14

作者：

TANDA, N

KAWAKAMI, Y

SAITO, T

NOJI, S

NOHNO, T

机构：

[1] Kawasaki Med Sch, DEPT PHARMACOL, KURASHIKI, OKAYAMA 70101, JAPAN

[2] Kawasaki Med Sch, DEPT HYG, KURASHIKI, OKAYAMA 70101, JAPAN

[3] UNIV TOKUSHIMA, FAC ENGN,DEPT BIOL SCI & TECHNOL, TOKUSHIMA 770, JAPAN

来源：

DNA SEQUENCE | 1995年 / 5卷 / 05期

关键词：

GROWTH FACTOR; WNT-4; WNT-11; CDNA; CHICK EMBRYO;

D O I：

10.3109/10425179509030981

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have isolated two members of the Wnt gene family, Wnt-4 and Wnt-11, from chick embryo cDNA library, and determined the entire coding sequences. The Wnt-4 and Wnt-11 genes encode secretory proteins composed of 351 and 354 amino acids, respectively, both having 24 Cys residues conserved among other Wnt family members. Alignment of the deduced amino acid sequences reveals that chicken Wnt-4 and Wnt-11 are most similar to Xenopus Wnt-4 and mouse Wnt-11, respectively. Northern blot analysis indicates the Wnt-4 expression at 1.5 kilobase and the Wnt-11 expression at 2.0 kilobase in the chick embryo.

引用

页码：277 / 281

页数：5

共 16 条

[1] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].