MOLECULAR-CLONING AND BINDING-PROPERTIES OF THE HUMAN TYPE-II ACTIVIN RECEPTOR

被引：83

作者：

DONALDSON, CJ

MATHEWS, LS

VALE, WW

机构：

[1] Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91194-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A full-length cDNA for the type II human activin receptor was cloned by hybridization from a human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99% identical, at the amino acid level, with the mouse type II activin receptor. The type II human activin receptor consists of an extracellular domain that specifically binds activin A with a Kd of 360 pM, a single-membrane spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity. © 1992.

引用

页码：310 / 316

页数：7