THE ONCOFETAL GENE PEM SPECIFIES A DIVERGENT PAIRED CLASS HOMEODOMAIN

被引：19

作者：

RAYLE, RE

机构：

[1] Miami University, Department of Zoology, Oxford

来源：

DEVELOPMENTAL BIOLOGY | 1991年 / 146卷 / 01期

关键词：

D O I：

10.1016/0012-1606(91)90467-H

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The polypeptide sequence predicted from the Pem oncofetal gene cDNA contains a homeodomain most closely related to the paired class. Pem, paired class member orthodenticle, and the bicoid maternal gene product homeodomains all have lysine residues at a recognition helix position implicated in DNA-binding specificity. The Pem recognition helix also has an isoleucine residue replacing an invariant asparagine residue and shares an asparagine residue at a third position with two other vertebrate homeoproteins, at least one of which binds to DNA only as a dimer. © 1991.

引用

收藏

页码：255 / 257

页数：3

相关论文

共 23 条

[1] THE SEQUENCE OF THE DNAS CODING FOR THE MATING-TYPE LOCI OF SACCHAROMYCES-CEREVISIAE [J].

ASTELL, CR ;

AHLSTROMJONASSON, L ;

SMITH, M ;

TATCHELL, K ;

NASMYTH, KA ;

HALL, BD .

CELL, 1981, 27 (01) :15-23

[2] STRUCTURE OF 2 GENES AT THE GOOSEBERRY LOCUS RELATED TO THE PAIRED GENE AND THEIR SPATIAL EXPRESSION DURING DROSOPHILA EMBRYOGENESIS [J].

BAUMGARTNER, S ;

BOPP, D ;

BURRI, M ;

NOLL, M .

GENES & DEVELOPMENT, 1987, 1 (10) :1247-1267

[3] THE ROLE OF LOCALIZATION OF BICOID RNA IN ORGANIZING THE ANTERIOR PATTERN OF THE DROSOPHILA EMBRYO [J].

BERLETH, T ;

BURRI, M ;

THOMA, G ;

BOPP, D ;

RICHSTEIN, S ;

FRIGERIO, G ;

NOLL, M ;

NUSSLEINVOLHARD, C .

EMBO JOURNAL, 1988, 7 (06) :1749-1756

[4] A DISTAL DIMERIZATION DOMAIN IS ESSENTIAL FOR DNA-BINDING BY THE ATYPICAL HNF1 HOMEODOMAIN [J].

CHOUARD, T ;

BLUMENFELD, M ;

BACH, I ;

VANDEKERCKHOVE, J ;

CEREGHINI, S ;

YANIV, M .

NUCLEIC ACIDS RESEARCH, 1990, 18 (19) :5853-5863

[5] BINDING OF YEAST A1 AND ALPHA-2 AS A HETERODIMER TO THE OPERATOR DNA OF A HAPLOID-SPECIFIC GENE [J].

DRANGINIS, AM .

NATURE, 1990, 347 (6294) :682-685

[6] THE ORTHODENTICLE GENE ENCODES A NOVEL HOMEO DOMAIN PROTEIN INVOLVED IN THE DEVELOPMENT OF THE DROSOPHILA NERVOUS-SYSTEM AND OCELLAR VISUAL STRUCTURES [J].

FINKELSTEIN, R ;

SMOUSE, D ;

CAPACI, TM ;

SPRADLING, AC ;

PERRIMON, N .

GENES & DEVELOPMENT, 1990, 4 (09) :1516-1527

[7] THE ORTHODENTICLE GENE IS REGULATED BY BICOID AND TORSO AND SPECIFIES DROSOPHILA HEAD DEVELOPMENT [J].

FINKELSTEIN, R ;

PERRIMON, N .

NATURE, 1990, 346 (6283) :485-488

[8] THE LIVER-SPECIFIC TRANSCRIPTION FACTOR LF-B1 CONTAINS A HIGHLY DIVERGED HOMEOBOX DNA-BINDING DOMAIN [J].

FRAIN, M ;

SWART, G ;

MONACI, P ;

NICOSIA, A ;

STAMPFLI, S ;

FRANK, R ;

CORTESE, R .

CELL, 1989, 59 (01) :145-157

[9] ORGANIZATION OF ANTERIOR PATTERN IN THE DROSOPHILA EMBRYO BY THE MATERNAL GENE BICOID [J].

FROHNHOFER, HG ;

NUSSLEINVOLHARD, C .

NATURE, 1986, 324 (6093) :120-125

[10] THE STRUCTURE OF THE HOMEODOMAIN AND ITS FUNCTIONAL IMPLICATIONS [J].

GEHRING, WJ ;

MULLER, M ;

AFFOLTER, M ;

PERCIVALSMITH, A ;

BILLETER, M ;

QIAN, YQ ;

OTTING, G ;

WUTHRICH, K .

TRENDS IN GENETICS, 1990, 6 (10) :323-329