PRENATAL AND EARLY POSTNATAL BETA-ADRENERGIC RECEPTOR-MEDIATED INCREASE OF CYCLIC-AMP IN SLICES OF RAT-BRAIN

被引：23

作者：

WALTON, KG ^{[1
]}

MILLER, E ^{[1
]}

BALDESSARINI, RJ ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,MAILMAN RES CTR,PSYCHIAT RES LAB,BELMONT,MA 02178

来源：

BRAIN RESEARCH | 1979年 / 177卷 / 03期

关键词：

D O I：

10.1016/0006-8993(79)90468-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The levels of cyclic AMP in slices of cerebral cortex and cerebellum from newborn rats were significantly, but transiently, increased by exposure to the β-adrenergic agonist, isoproterenol. Isobutylmethyxanthine, an inhibitor of phosphodiesterase, enhanced this effect and permitted its detection in cerebral cortex obtained from the prenatal rat. These results are consistent with the possibilities that functional noradrenergic synapses are formed early in the ontogeny of the CNS, and that norepinephrine may exert cyclic AMP-mediated influences on brain development. © 1979.

引用

页码：515 / 522

页数：8

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